导师类型

博导

办公地点

6-107

职称/职务

教授/系主任

电子邮箱

huangchao@sicau.edu.cn

研究方向

哺乳动物神经与雄性生殖系统发育/疾病发生中关键基因的功能解析、动物疾病模型的构建

教育背景及工作经历

2021.12至今，yl34511线路中心，教授；

2017.12-2021.11，yl34511线路中心，副教授；

2015.1-2017.11，yl34511线路中心，讲师；

2014.7，四川大学华西医院生物治疗国家重点实验室，获理学博士学位；

2009.7，四川大学生命科学学院，获理学学士学位；

教学课程

动物解剖学、实验动物学

科研项目

1、四川省科技厅，四川省杰出青年科学基金，2023-2025，在研，主持

1、国家自然科学基金，面上项目，2021-2024，在研，主持

2、国家自然科学基金，面上项目，2019-2022，结题，主持

3、国家自然科学基金，青年基金，2016.01-2018.12，结题，主持；

主要论著、

代表性论文

近年来，以第一或通讯作者发表的代表论文如下：

1. Animal models of male subfertility targeted on LanCL1-regulated spermatogenic redox homeostasis.Lab Animal, 2022, 51, 1-13 (Cover Article).

2. Developmental and activity-dependent expression of LanCL1 confers antioxidant activity required for neuronal survival,Developmental Cell, 2014, 30, 479-487（Featured Article）

3. PGC-1α-Coordinated Hypothalamic Antioxidant Defense Is Linked to SP1-LanCL1 Axis during High-Fat-Diet-Induced Obesity in Male Mice.Antioxidants.13.2 (2024): 252.

4. LanCL2 implicates in testicular redox homeostasis and acrosomal maturation.Antioxidants. 13.4 (2024)

5. Effects of Solid Fermentation on Polygonatum cyrtonema Polysaccharides: Isolation, Characterization and Bioactivities.Molecules28.14 (2023): 5498.

6. Polysaccharide from Salviae miltiorrhizae Radix et Rhizoma Attenuates the Progress of Obesity-Induced Non-Alcoholic Fatty Liver Disease through Modulating Intestinal Microbiota-Related Gut–Liver Axis. International Journal of Molecular Sciences23.18 (2022): 10620.

7. Loss of TRIM67 attenuates the progress of obesity-induced non-alcoholic fatty liver disease.International Journal of Molecular Sciences23.13 (2022): 7475.

8. BAF-L Modulates Histone-to-Protamine Transition during Spermiogenesis.International Journal of Molecular Sciences, 2022, 23, 1985

9. Pectic polysaccharide from Nelumbo nucifera leaves promotes intestinal antioxidant defense in vitro and in vivo, FOOD & FUNCTION, 2021, DOI: 10.1039/d1fo02354c

10. Tumor grade related expression of neuroglobin is negatively regulated by PPARγ and confers antioxidant activity in glioma progression.Redox biology. 2017, 12, 682-689.

11. Characterization of an antioxidant pectic polysaccharide from Platycodon grandifloras,International Journal of Biological Macromolecules. 2021, 175, 473-480.

12. A pectic polysaccharide from water decoction of Xinjiang Lycium barbarum fruit protects against intestinal endoplasmic reticulum stress.International Journal of Biological Macromolecules. 2019, 130, 508-514.

13. A pectic polysaccharide from Ligusticum chuanxiong promotes intestine antioxidant defense in aged mice.Carbohydrate polymers. 2017, 174, 915-922.

14. Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-kappaB pathway.Biology open. 2020, 9.

15. Iron overload resulting from the chronic oral administration of ferric citrate induces parkinsonism phenotypes in middle-aged mice.AGING-US. 2019, 11, 9846-9861.

16. Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide.Oxidative medicine and cellular longevity. 2019.

17. A Pectic Polysaccharide from Sijunzi Decoction Promotes the Antioxidant Defenses of SW480 Cells.Molecules. 2017, 22, 1341.

18. Soy Isoflavones regulate lipid metabolism through an AKT/mTORC1 pathway in diet-induced obesity (DIO) male rats.Molecules.2016, 21, 586.